Investigation of C-reactive protein and AIM2 methylation as a marker for PTSD in Australian Vietnam veterans

Chronic inflammation is a key factor in symptomology and comorbidities of post-traumatic stress disorder (PTSD). Levels proinflammatory marker, C-reactive protein (CRP) are increased individuals with PTSD but it not clear if this due to trauma exposure or PTSD. Our study aimed assess the relationship between serum CRP levels, SNPs, methylation, mRNA expression homogenous exposed Australian Vietnam veteran cohort. We hypothesized that decreased DNA methylation would be associated gene peripheral levels patients independent trauma. Participants were 299 veterans who had all been approximately half diagnosed observed higher group compared non-PTSD after controlling for BMI triglycerides association did remain significant. No was found SNPs levels. Absent Melanoma 2 (AIM2) which mediator inflammatory response determinant analysed expression. trend level AIM2 age, smoking, triglycerides, cell types. There no significant interaction on covariates. as decreased, increased. Elevated cohort there effect results could confirm marker older veterans. may broad disease risk, younger cohorts than those study.